ET (http://cancerres.aacrjournals.org/content/69/17/6978.full#ref-list-1)Tj endobj 0 1 TD (\240 )Tj If this tutorial is part of the member benefit package, Fellows, Members, registered Trainees and Associates should sign in to access the tutorial. /T1_0 1 Tf 50 0 obj Just like scalpels, lasers, and electric currents are used in surgery, the weapons used to fight cancer in chemotherapy are a host of anti-cancer drugs. 0 g 0 0 1 rg Classification of anticancer drugs based on their differential impacts on DCs ( A ) Each drug was tested at 5 different doses (0.1-10 μ M) for its efficacies to elevate YFP /T1_3 1 Tf ET You can access the Principles of chemotherapy tutorial for just £48.00 inc VAT. BT 29 0 obj (\(CCC\))Tj /T1_3 1 Tf -5.77898 0 Td 36 0 obj Q Types of Chemotherapy Drugs. (\240 )Tj 17 0 obj )Tj ��UA�;�4���,������eTUe� �2tk��� 6��&b��ij�WREA�n�>�لaQz�͹�j�R���,�>w;�f����o[���������L,��H;���*�5 9 0 0 9 269.74257 1.99997 Tm (Hiroaki Tanaka, Hironori Matsushima, Norikatsu Mizumoto, et al. BT Chemotherapy remains the standard treatment modality for many advanced cancers, although it is neither curative as a stand-alone protocol nor effective in augmenting host immune responses to cancer cells. 10 0 0 10 141 369.99994 Tm -5.66901 1 Td 16.67599 1 Td <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Type/Page>> 23.17896 1 Td 11 0 0 11 120.94202 377.99997 Tm (\240 )Tj ET BT (\240 )Tj 9 0 0 9 132.91908 770 Tm (http://cancerres.aacrjournals.org/content/69/17/6978)Tj T* -30.29194 0 Td (\240 )Tj (Click on "Request Permissions" which will take you to the Copyright Clea\ rance Center's)Tj BT 0 1.00001 TD ( )Tj 11 0 0 11 120.94202 284.99994 Tm (\240 )Tj You do not currently have access to this tutorial. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Type/Page>> ET 11 0 0 11 120.94202 407.99997 Tm 0 1.00001 TD BT Acrobat Distiller 4.05 for Windows Access the ar\ ticles at:)Tj 1 0 obj BT T* (\240 )Tj /T1_0 1 Tf (doi:)Tj How differently these drugs kill cancer cells, or prevent them from dividing, depends on their classification. Classification of chemotherapy drugs. (Sign up to receive free email-alerts)Tj 2009-08-25T19:23:02Z Different types of chemo drugs work on different phases of the cell cycle. Z�eY�$���߰�e:���y�߭qk���NtD��QY�o����Q��q�j�TN4砎��t���`w�Z~QkX���VU�T&N\P���H/%�Xe�J��r��պ�� -28.90194 0 Td -6.85098 0 Td BT 0 1 TD 0 g 30.29194 1 Td 11 0 0 11 120.94202 317.99997 Tm 10 0 0 10 141 482.99994 Tm (http://cancerres.aacrjournals.org/content/69/17/6978.full#related-urls)Tj 23 0 obj Chemotherapeutic agents, also referred to as antineoplastic agents, are used to directly or indirectly inhibit the proliferation of rapidly growing cells, typically in the context of malignancy.They are classified according to their mechanism of action and include alkylating agents, antimetabolites, topoisomerase inhibitors, and mitotic inhibitors. /T1_0 1 Tf (\240 )Tj -15.44997 0 Td 0 0 1 rg 540.0594177 0 0 68.6011963 22.4702911 666.3988037 cm 10 0 0 10 141 399.99994 Tm (This article cites 32 articles, 14 of which you can access for free at:)Tj endobj (\240 )Tj ET (. S /T1_2 1 Tf ( )Tj 2020-10-10T01:06:06-07:00 endstream /T1_2 1 Tf endobj -6.61399 0 Td /T1_3 1 Tf 15 0 obj BT BT ( related to this article or journal. %PDF-1.4 %���� 0 0 m 10 0 0 10 295.49973 330 Tm Most chemotherapy drugs kill cancer cells outright, or stop their reproduction and spread by inhibiting metabolic functions of the cancer cell. /T1_0 1 Tf H���M�UI����~� �͇�1�3ZpcBO��ǂ7nԅ�$�BM�Q�!a=n��c&&�gC������@ $>���w������=3��o1���v��U�N��^\q ���a� ���ȰS @�Dd�) �m"2� �6v They can also act on healthy cells (because they also divide) which is the basis for side effects and unwanted complications of therapy. 0 1.00001 TD 0 0 1 rg 10 0 0 10 85.56992 567.99985 Tm 2020-10-10T01:06:06-07:00 <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>> )Tj Chemotherapy drugs may be be classified as follows- Alkylating agents (or) DNA- damaging agents Alkylating agents act by chemically altering the cellular DNA.They add alkyl groups to … … endobj -15.06398 0 Td BT 10 0 0 10 30 459.99997 Tm <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Type/Page>> ET /T1_0 1 Tf 45 0 obj endobj (\240 )Tj )Tj (\240 )Tj <>stream endobj /T1_0 1 Tf The cell cycle is a series of phases that all cells, both normal and cancerous, go through to form new cells. (\240 )Tj ET -3.50099 1 Td -6.00198 1 Td /T1_3 1 Tf /T1_3 1 Tf 0 0 1 rg -39.57494 0 Td /T1_0 1 Tf 129 0 obj 0 g (Access the most recent supplemental material at:)Tj endobj 159 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Type/Page>> (In vitro)Tj 3B2 Total Publishing 6.06b/W BT (on October 10, 2020. 127 0 obj -6.38997 1 Td 0 g /T1_0 1 Tf -5.55699 0 Td (Reprints and )Tj -1.34302 1 Td /T1_2 1 Tf <>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>> �fiec�Ҷ#�Ժ��Ft�fϺ�a{�%���a��5bݡ�*S{ʚ�mV���OdmK��r9 �b߭�?�z����X�e����`ii���۶m���Ѫ���_�D}���i�8��_�����������Ea�^UY���V�Ç/]�t����ׯ߿aaAW�v����{��ٻw�7��s���N����t��LXs��A݃�{�\��=��J�������;ۋfI���&7�s��ɱ��8Yq�nK���#�V����ⲑ0���Y>���I���l�>��M����K_�O-�O�W�.���r��>T���Gi{l&拯ouэs_Vr�f���ΎI�[�F���j��~��1{c��lE� A�y��9�V���j���h_��>ְ�~�v�*�ֆ���\ >?��O����ݑn��K�T�d�CU?c���^�p��X]����go���ߎ9R��H:RU���WY�i�{��M}q����4f�s�/�?~nn�ٓ'�d�;:99966��tk���G��?Mҙ�����ǎ���ҹ!C���7Ĺ������_�����F��{"b9�^*W����l�ٺ������z��_�z��q�+⪒� ��[Ӕ�Z�W���g��y�kUu�A�����n�km=A���K�v�M��Ў������o�޿����� ~�űWV���ֹq�f�^�N�Te�m�ba���'ޘ�ju|P��ٌ��ӪaK7s�ڣ�6�Z_u:�еk׶lٲ{�n߇m�m��k��֭[���������{o޴uѤ�17 >#RVO���ӧ7n�������_������˲��H��~�������ofY��q���8Mӏ�|t���SgN���C�q���S�N]�x1�㉉�Mcc�ik�?P��,,,S'O����w�m���zH�|� uuid:ee0eb4bb-1dd1-11b2-0a00-980827fd5800 10 0 0 10 141 287.99994 Tm 53 0 obj (. 0 1.00001 TD /T1_0 1 Tf The S phase is where chromosomes are copied so the 2 new cells that will be created will have identical DNA. h��; �MD�� �&"�N �9�ߤATEFQ!��� ����°�(�2��WZ��h�� ���Nk;����s�*�C��`mD�QEǶhV䝸�Ͳ,I�ٖ�z�+�"��"^JWF{���k��ի[�H\꺑�tJ?��UaQW=����.J�NPu�3?��E3�4�{Y@�.����0v�jn��m��W:���>u�� ���8>�Ƭ��5G�X�9�_�@+1��׉�\�S;��|�fA�a��7�%�'�a6W�G�yY�Ő�*����\ ������ͽ[�~�U}����]T�! 0 1 TD /T1_0 1 Tf /T1_2 1 Tf -23.17896 0 Td 30 370 525 70 re ET 0 g (cancerres.aacrjournals.org )Tj T* 0 0 1 rg (\240 )Tj (Rightslink site. S 165 0 obj /T1_2 1 Tf uuid:ee0eb4bf-1dd1-11b2-0a00-6a0000000000 (Department at)Tj 11 0 0 11 120.94202 479.99994 Tm -3.44499 1.00001 Td BT ( )Tj (Cancer Res\240)Tj ET 10 0 0 10 30 349.99997 Tm PDF | The arrival of a great number of new antineoplastic agents has made it necessary to reclassify all of them. (Updated version)Tj There are many kinds of chemo drugs. (Material)Tj (\240 )Tj /T1_1 1 Tf -3.33398 0 Td /T1_4 1 Tf (10.1158/0008-5472.CAN-09-1101)Tj 10 0 0 10 141 224.99985 Tm ET endobj h��; �MD�� �&"�N m�a� ���ȰS @�Dd�) �m"2� �6v 0 0 1 rg /T1_0 1 Tf (\240 )Tj /T1_2 1 Tf (\240 )Tj ET 0 0 1 rg 160 0 obj 0 1 TD )Tj (To request permission to re-use all or part of this article, use this li\ nk)Tj [166 0 R 167 0 R 168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R] <> \251 2009 American Association for Cancer)Tj ( )Tj 0 g ET (\240 )Tj 30 225 525 125 re 10 0 0 10 30 439.99997 Tm The cycle begins with the cell in a resting phase. ET ET -12.11496 0 Td h��; �MD�� �&"�N m�a� ���ȰS @�Dd�) �m"2� �6v <>stream 0 1 TD /T1_0 1 Tf -8.11398 0 Td 0 1.00001 TD endobj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>> ET �������qE6����K�����֑UPVU5^�V�칕���|�|y~�ͱ]o�����|5��"\I� ZdY��]���Z�A����-��_�. BT Published OnlineFirst August 25, 2009. (\240 )Tj (To order reprints of this article or to subscribe to the journal, contac\ t the AACR Publications)Tj 0 0 m BT (Cited articles)Tj 18 0 0 18 194.0332 607.99997 Tm <>/Font<>/ProcSet[/PDF/Text]>>/Type/Page>> ET /T1_3 1 Tf endobj 0 g <>/Filter/FlateDecode/Height 196/Length 86651/Name/X/Subtype/Image/Type/XObject/Width 1543>>stream /T1_0 1 Tf endobj /Im0 Do q These drugs are called cytotoxic. In the G1 phase, the cell grows larger and begins to make proteins. (Citing articles)Tj 0 1.00001 TD 0 0 m (pubs@aacr.org)Tj 10 0 0 10 141 512.99994 Tm 0 g /T1_0 1 Tf ET (This article has been cited by 9 HighWire-hosted articles. 30 480 525 68 re )Tj 11 0 0 11 120.94202 262.99997 Tm S 13.46497 1 Td 0 1 TD (Research. 0 0 1 rg (\240 )Tj Preface: The development of effective drugs for the treatment of cancer represents a significant achievement beginning with the discovery of the antimetabolites and alkylating agents in the 1940s and 1950s. ( Effects on Dendritic Cells)Tj endobj (Permissions)Tj BT /T1_2 1 Tf Physicians’ Cancer Chemotherapy Drug Manual 2019 PDF Free Download . /T1_0 1 Tf BT (http://cancerres.aacrjournals.org/content/suppl/2009/08/21/0008-5472.CAN\ -09-1101.DC1)Tj application/pdf <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>> 39.57494 1 Td (Differential )Tj 11 0 0 11 120.94202 520.99997 Tm endobj <>/Font<>/ProcSet[/PDF/Text]>>/Type/Page>> /T1_0 1 Tf ET (Subscriptions)Tj 41 0 obj (\240 )Tj /T1_0 1 Tf (Published OnlineFirst August 25, 2009; DOI: 10.1158/0008-5472.CAN-09-110\ 1 )Tj -7.55696 1 Td -6.33498 1 Td -5.66901 1 Td UK prices shown, other nationalities may qualify for reduced prices. endstream endobj BT BT T* <> (\240 )Tj /T1_3 1 Tf /T1_2 1 Tf (Downloaded from )Tj -1.61201 0 Td /T1_3 1 Tf (Classification of Chemotherapeutic Agents Based on Their)Tj 130 0 obj /T1_3 1 Tf ET BT (E-mail alerts)Tj 28.90194 1 Td 0.556 1.00001 Td ET BT )Tj endobj (2009;69:6978-6986. /T1_0 1 Tf (Access the most recent version of this article at:)Tj (Supplementary)Tj )Tj 09-1101 6978..6986 You can access the Principles of chemotherapy tutorial for just £48.00 inc VAT of.... 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